| 2021-11-27 18:00:0027/11/2021 | Melipilla  | 1 - 0 | Everton | N/A |
| 2021-11-27 18:00:0027/11/2021 | Cobresal | 0 - 0 | Universidad de Chile | N/A |
| 2021-11-27 18:00:0027/11/2021 | O’Higgins | 0 - 0 | Antofagasta | N/A |
| 2021-11-28 12:00:0028/11/2021 | Santiago Wanderers | 2 - 2 | Audax Italiano | N/A |
| 2021-11-28 18:00:0028/11/2021 | Universidad Católica | 18:00:0018:00 | Huachipato | N/A |
| 2021-11-28 18:00:0028/11/2021 | Curicó Unido | 1 - 1 | Palestino | N/A |
| 2021-11-28 18:00:0028/11/2021 | Unión La Calera | 1 - 2 | La Serena | N/A |
| 2021-11-28 18:00:0028/11/2021 | Colo Colo | 0 - 1 | Unión Española | N/A |
Everton
Universidad de Chile
Antofagasta
Audax Italiano
Huachipato
Palestino
La Serena
Unión Española